Endocrine Abstracts

Introduction: Parabens, esters of para-hydroxybenzoic acid, are widely used as an antimicrobial agent in the cosmetic products and pharmaceutical industries. Recently, it has been reported that parabens including methyl-, ethyl-, propyl-, butyl-, isopropyl-, and isobutylparaben act as xenoestrogens, a class of endocrine disruptors. In this study, we hypothesized that parabens may disrupt ovarian follicle maturation in female rats during the neonatal period.<p class="abstex...

Cellular Ca2+ signals have been proposed to activate signal for hormone secretion. In pancreatic β cell which produce insulin, Ca2+ signals have been known contributing insulin secretion. Prior to conduct this study, we confirmed Calbindin-D9k (CaBP-9k) which responsible for regulation of the distribution of free calcium in the cytoplasm. We confirmed Insulin-secreting β cell express CaBP-9k and assumed that CaBP-9k play a certain role in β...

Introduction: Microalbuminuria is known as a predictor of cardiovascular disease (CVD) in patients with and without diabetes, as well as the general population. The objective was to determine whether there was an association between the urinary albumin excretion and CVD risk by estimating the Framingham Risk Score (FRS) in nondiabetic middle-aged adults.Methods: This study was based on data from the Korea National Health and Nutrition Examination Survey,...

Objective: This study aims to investigate whether DHEAS (Dehydroepiandrostenedione sulfate) inhibit the growth of leiomyoma.Method: Total 131 patients were recruited according to the leiomyoma size by transvaginal ultrasonography. Excluding twenties and over fifties, 88 patients were analyzed. The leiomyoma group was classified into three groups, such as mild, moderate and severe. The mild group was defined as the presence of at least one or two leiomyom...

Introduction: Hypoxia is involved with various physiological activities from glucose metabolism to tumor suppression. Hypoxia-inducible factor (HIF) is known as master regulator of oxygen homeostasis that triggers more than 1,000 related gene expressions. When hypoxia occurs, HIF1a protein is stabilized and starts transcription. Mucin1 mediates the stabilization of HIF1a in a cytoplasm. In addition, cytoplasmic domain of mucin1 and HIf1a form a transcriptional complex at glyco...

Objective: In this study, we investigated the utility of Doppler and microvascular imaging in diagnosing benign and malignant thyroid nodules according to the TI-RADS (Thyroid Imaging Reporting and Data System) and pathologic subtypes of thyroid malignancy.Methods: Total 113 pathologically confirmed thyroid nodules (n =72 (63.7%) benign, n =41 (36.3%) malignant) from103 patients who visited for evaluation of thyroid nodules in single te...

Objective: Having a psychiatric disorder may increase the risk of developing type 2 diabetes (T2D) and we aimed to determine whether young adults with a psychiatric disorder have an increased risk of developing T2D.Research Design and Methods: We conducted a nationwide cohort study to evaluate the association of different psychiatric disorders with the risk of T2D in the young population. Records of 6.457.991 adults aged 20−39 years without a histo...

Background: The National Health Insurance Service of South Korea is considered to be one of the most effective systems in the world with high accessibility to health care for all Koreans including foreign residents in the country as many as 50 M people. The accumulative information on the behaviors and the statistics of healthcare use based on the National Health Insurance Sharing Service Database has become important for medical research as a nationwide surveillance.<p cl...

Objective: Sarcopenic obesity is a double burden for older people because it carries the cumulative risk of functional abnormality, metabolic, cardiovascular risk, and mortality compared to either sarcopenia or obesity alone. Diabetes is related to an increase in visceral adiposity and is associated with the risk of sarcopenia. The objective was to explore the association between sarcopenic obesity and diabetes and determine the associated factors with sarcopenic obesity in ol...

It has been proposed that cellular Ca2+ signals activate hormone secretion. In pancreatic β cells, which produce insulin, Ca2+ signals have been known to contribute to insulin secretion. In previous study, demonstrated that endocrine disrupting chemicals (EDCs) such as bisphenol A (BPA) and Octylphenol (OP) could cause increase in insulin level and insulin transcription factors. But in regulations of plasma glucose level were not decreased as much as...